BRAF Mutation analysis: A new tool for Pathologists in metastatic Melanoma; Multicenter retrospective evaluation on 239 cases in French private pathologists laboratories
Jérôme Chetritt1, Nicolas Josselin1, Alain Gaillot2, Claude Desplechain2, Emmanuel Watkin3, Philippe Chalabreysse3, Delphine Raoux4, Nicolas Weinbreck4
1 IHP Nantes; 2 Sipath Clermont-Ferrand; 3 Cypath Lyon; 4 Medipath Frejus
BRAF tumor V600 mutation status has to be evaluated with a molecular test for targeted therapy.
In France, such onco-molecular tests are performed in centralised Institutional Molecular Biology Platforms under INCA’s control (National Cancer Institute). Time to result and consolidated data are crucial for oncologists.
Through a feasibility study we evaluated our capacity to use in our labs a novel fully automated system which gives BRAF V600 mutation status directly from formalin-fixed paraffin-embedded (FFPE).